August 28, 2017 Chooi Ling, Lim

Designation/Title : Dr
Department: Human Biology
Tel: 03-27317611 (Ext. 2761)
E-mail : chooi_linglim@imu.edu.my

Education and Training

PhD University Putra Malaysia 2010
BSc University Putra Malaysia 2006

 

Research interests:

  • TGF-? signaling in liver fibrosis and quiescence of hepatic stellate cells
  • Secondary metabolites of Actinomyces (Streptomyces sp.)
  • Bioactivity of edible bird nest on UV-irradiated keratinocytes
  • Modulatory effect of Kappaphycus alvarezii on endopeptidase activity in chondrocytes
  • p53 isoforms in breast and pancreatic cancers

Research projects/grants:

  • Comparative effects of edible bird nest, ‘sea bird nest’, and carrageenan on aquaporin-3 expression and migration of UV-irradiated normal human epidermal keratinocytes,
    Bachelor of Medical Science (BMedSc) project, International Medical University
    Mar 2012 – Nov 2012 – Principal Researcher
  • Epidermal growth factor receptor (EGFR)-mediated rescue of downregulated aquaporin 3 (AQP3) in ultra violet (UV)-irradiated human keratinocytes by edible birdnest (EBN), 
    Fundamental Research Grant Scheme (FRGS), Ministry of Higher Education (MOHE),
    2011 – 2012 – Principal Researcher
  • Comparative effects of edible bird nest, ‘sea bird nest’, and carrageenan on aquaporin-3 expression and migration of UV-irradiated normal human epidermal keratinocytes,
    Bachelor of Medical Science (BMedSc) project, International Medical University
    Mar 2012 – Nov 2012 – Principal Researcher
  • Antioxidant and reactive oxygen species (ROS) scavenging effects of Eucheuma cottonii on human keratinocytes, BSc (Hons) Biomedical Science project, International Medical University
    2013 – Principal Researcher
  • Toxicity and effect of Kappaphycus alvarezii extracts on the expression of endopeptidase enzymes TIMP-1, MMP-1, and MMP-13 in human chondrocytes, Bachelor of Medical Science (BMedSc) project, International Medical University
    2013 – Principal Researcher
  • Reversal of age-related hyposalivation by upregulation of salivary gland aquaporins, Exploratory Research Grant Scheme (ERGS), Ministry of Higher Education (MOHE),
    2013 – 2016 – Co-Researcher
  • Potential cytotoxic effect of Kappaphycus striatum and Kappaphycus alvarezii extracts in colorectal, cervical, and liver cancer cell lines, BSc (Hons) Biomedical Science project, International Medical University
    2014 – Principal Researcher
  • Differential expression of the p53 family in mammosphere-forming breast cancer cell lines, BSc (Hons) Biomedical Science project, International Medical University
    2016 – Principal Researcher
  • Regulation of cancer cell epithelial-mesenchymal plasticity (EMP) by p53 gain-of-function mutations, Fundamental Research Grant Scheme (FRGS), Ministry of Higher Education (MOHE),
    2016 – 2018 – Principal Researcher
  • Roles of Receptor Interacting Protein Kinase 1 in beta-Amyloid Deposition in Alzheimer’s Disease, Fundamental Research Grant Scheme (FRGS), Ministry of Higher Education (MOHE),
    2016 – 2018 – Co-Researcher
  • Functional roles of p53 mutants in the regulation of epithelial mesenchymal transition (EMT), cell cycle, histone modifications and PI3K signaling in pancreatic cancer cells, Bachelor of Pharmacy research project, International Medical University
    2017 – Principal Researcher
  • p53 family isoform expression and effect on survival of pancreatic cancer cell lines, BSc (Hons) Biomedical Science project, International Medical University
    2017 – Principal Researcher

Supervision of Postgraduates (MSc/PhD)
(Last 5 years – 2012-2017)

  • Chua Ming Jang  - MSc. (2010 – 2013)  - Co-supervisor
    Inhibition of cancer cell proliferation and survival through synergistic effects of traditional anti-cancer drug action in combination with target knockdown of cancer-related genes
  • Andy Goh Wei Shen – MSc. (2016 – current) – Co-supervisor
    An Investigation into Therapeutic Modulation of Aquaporin Five Expression in Salivary Gland Cells

Professional affiliations:

  • Member of the Malaysian Society for Biochemistry and Molecular Biology (MSBMB), 2010 – current
  • Exco member of the Malaysian Malaysian Biomedical Science Association (MyBiomed), 2016 - current

Academic Awards:

  • Nutrition Society of Malaysia (NSM) 21st Scientific Conference 30-31 March 2006 (Best Poster Prize – Consolation)
  • KUTPM Students Symposium Series on Biomedicine No: 2 (3rd Best Oral Presenter) 2006
  • Teguh Pharma Award 2006 for Excellence in Pathology [BSc (Biomedical Science) Hons]
  • National Science Fellowship Scholarship (Ph.D.) 2006-2009
  • International Seminar of Indonesian Society for Microbiology (ISISM), 4 – 7 Oct 2010 (Best Oral Presenter)
  • 1st International Conference on Nutraceutical and Cosmetic Sciences (ICNaCS) (22-23 Oct 2012), Istana Hotel, Kuala Lumpur, Malaysia. (3rd Best Oral Presenter)

Recent publications 
(last 5 years – 2012 -2017)

  • Kang YB, Mallikarjuna PR, Fabian DA, Gorajana A, Lim CL, Tan EL. Bioactive molecules: current trends in discovery, synthesis, delivery and testing. IeJSME 2013:7 (Suppl 1): 32-46. Review
  • Metabolites from Actinomyces Strain H6552 Extract Inhibit Transforming Growth Factor-Mediated Pulmonary Fibrosis. Rhun Yian Koh, Chooi Ling Lim, Coy Choke Ho, Bruce David Uhal, Maha Abdullah, Sharmili Vidyadaran and Heng Fong Seow. Tropical Journal of Pharmaceutical Research. 2014; 13 (11): 1815-1823. (IF: 0.820)
  • Rhun Yian Koh, Chooi Ling Lim, Bruce David Uhal, Maha Abdullah, Sharmili Vidyadaran, Coy Choke Ho, Heng Fong Seow. Inhibition of transforming growth factor-? via the activin receptor-like kinase-5 inhibitor attenuates pulmonary fibrosis. 2015. Molecular Medicine Reports. 11:3808-3813. (IF: 1.17)
  • Chooi Ling Lim, Rhun Yian Koh, Tatt Yhew Haw and Laura A. Boudville. Antioxidant Activity of the Sea Bird Nest (Eucheuma cottonii) and its Radical Scavenging Effect on Human Keratinocytes. Journal of Medical and Bioengineering. 2015; 4(6):461-165.
  • Lim HJ, Koh RY, Lim CL. Updates on Hepatic Stellate Cell Involvement in Liver Fibrosis. J Med Discov. 2016; 1(1).
  • Mohammed Shoaib NN, Lim CL, Koh RY. Functional roles of receptor interacting protein kinase 1 in Alzheimer’s disease. J Med Discov. 2017; 2(1).
2018-01-09T06:12:29+00:00