October 26, 2017 Chun Wai, Mai

Designation/Title : Lecturer, Dr
Department: Pharmaceutical Chemistry, School of Pharmacy
Tel: +603 2731 7596
E-mail : chunwai_mai@imu.edu.my

Education and Training

SEA-EU-NET II Fellowship European Union 7th Framework Programme 2016
Visiting Researcher National Research Council, Italy 2016
YPASM Research Fellow British Antarctic Survey, Cambridge, United Kingdom 2015-2016
PhD (Medicinal Chemistry) International Medical University, Malaysia 2014
Basic Teaching Licence International Medical University, Malaysia 2014
Research Fellow/Visiting Researcher University of Strathclyde, Glasgow, United Kingdom 2013
Good Clinical Practice Certificate Ministry of Health, Malaysia 2012
Registered Pharmacist Malaysia Pharmacy Board, Malaysia 2009
BPharm (Hons), First Class International Medical University, Malaysia 2009

 

Research interests:

  • Drug Discovery
  • Cancer
  • Inflammation and Immunology
  • Pharmaceutical Education

Research projects/grants:

  • Fundamental Research Grant Scheme (FRGS) (2017-2019) for “Mechanistic basis of tumour evasion from cytotoxic T cells (CTL) surveillance in pancreatic cancers” (Principle Investigator – RM146,916.00)
  • Universiti Tunku Abdul Rahman Research Fund (2017) for “Microwave-assisted synthesis, inhibitory activities, and structure-activity relationship of 4-phenylcoumarin derivatives as inhibitors of growth of human nasopharyngeal cancer cell lines.” (Co-investigator – RM 49,000.00)
  • International Medical University (IMU) (2017) for “Evaluation of Antimicrobial Activity of Antarctica Fungal Alkaloids on Antibiotic-Resistant Escherichia coli” (Co-investigator – RM 3,000.00)
  • International Medical University (IMU) (2017) for “The effect of tetrahydro-isoquinolines against antibiotic-resistant Campylobacter sp.” (Principle investigator – RM 6,000.00)
  • International Medical University (IMU) (2017) for “Drug discovery from marine extremophile: new antibacterial compounds from marine sources.” (Principle investigator – RM 6,000.00)
  • International Medical University (IMU) (2017) for “Targeting the specific molecular subtypes of pancreatic cancers through combinatorial therapy.” (Co-investigator – RM 12,000.00)
  • International Medical University (IMU) (2017) for “Anticancer Activities of Hybridised Silver Nanoparticle-Graphene Oxide Nanocomposite (AgNP-GO).” (Co-investigator – RM 12,000.00)
  • International Medical University (IMU) (2017) for “Antitumor activities of novel molecular hybrids consisting chalcone-2,4-thiazolidinedione moieties.” (Co-investigator – RM 10,000.00)
  • Malaysia Palm Oil Board (MPOB) (2016-2018) for “Effect of Palm Carotene Mix on Molecular Targets Implicated in Human Disease : A High Throughput Screening Approach” (Co-investigator – RM315,000.00)
  • Fundamental Research Grant Scheme (FRGS) (2016-2019) for “Chemical profiling, dereplication and isolation of new and cytotoxic chemical constituents from Goniothalamus lanceolatus” (Co-investigator - RM147,800.00)
  • Fundamental Research Grant Scheme (FRGS) (2016-2018) for “Functional roles of sphingosine kinase 1 (SPHK1) in human breast cancer stem cells” (Co-investigator - RM103,000.00)
  • International Medical University (IMU) (2016) for “Collaborative high throughput screening for the discovery of molecules modulating NFkB, p53, LXR and PPARg.” (Pinciple investigator – RM 12,000.00)
  • International Medical University (IMU) (2016) for “Antibacterial properties of bacteria isolated from mangrove soil.” (Pinciple investigator – RM 2,000.00)
  • International Medical University (IMU) (2016) for “Impacts of gamification to the knowledge gained and learning among healthcare students.” (Pinciple investigator – RM 1,200.00)
  • International Medical University (IMU) (2016) for “Evaluation of growth condition for production of secondary metabolites in fungal isolates from Antarctic soil. ” (Co-investigator – RM 4,500.00)
  • International Medical University (IMU) (2016) for “Mechanism of the antitumour activity of piperlongumine analogues in non-stem breast cancer cells and breast cancer stem cells (CSCs).” (Co-investigator – RM 20,000.00)
  • International Medical University (IMU) (2015) for “Establishing the metabolic effects of Clinacanthus nutans in macrophages using metabolomic approaches.” (Co-investigator – RM 4,500.00)
  • International Medical University (IMU) (2015) for “Molecular mechanisms and antitumor potentials of cudraflavone C in breast and colorectal cancers.” (Principle investigator – RM 20,000.00)
  • International Medical University (IMU) (2015) for “Discovery of new anticancer pharmacophores through collaborative high-throughput phenotypic screen” (Co-investigator – RM 12,000.00)
  • International Medical University (IMU) (2015) for “Evaluation of the anti-cancer properties of the 1,3-dichlorobutan-2-amine derivatives in vitro” (Co-investigator – RM 12,000.00)
  • Fundamental Research Grant Scheme (FRGS) (2015-2018) for “System biology comparison between mice with single and co-infection from Toxoplasma gondii and/or Trypanosoma evansi” (Co-investigator - RM162 000.00)
  • Yayasan Penyelidikan Antartika Sultan Mizan (YPASM) Research Fellowship (2015-2016) for “The antifungal effects of bacteria isolated from Antarctic soil.” (Principle Investigator - RM 49,949.10)
  • International Medical University (IMU) (2015) for “Anticancer metabolite from Antartic orithogenic soil bacteria” (Principle Investigator – RM 12,000.00)
  • International Medical University (IMU) (2015) for “Evaluation of the anti-cancer properties of the 1, 3-dichlorobutan-2amine derivatives in vitro” (Co-investigator – RM 12,000.00)
  • International Medical University (IMU) (2015) for “Discovery of new anticancer pharmacophores through collaborative high-throughput phenotypic screen.” (Co-investigator – RM 15,000.00)
  • International Medical University (IMU) (2014-2016) for “Interprofessional learning amongst health professions students: a trajectory to consolidate professionalism” (Co-investigator - RM15,700.00)
  • International Medical University (IMU) (2014-2015) for “Molecular mechanisms and antitumor potentials of cudraflavone C in breast and colorectal cancers.” (Principle Investigator – RM 20,000.00)
  • International Medical University (IMU) (2014-2015) for “Effects of lutein (LUT) and zeaxanthin (ZEA) in modulating the DICER1 expression in human retinal pigment epithelium cells under oxidative stress.” (Co-investigator – RM 20,000.00)
  • Notthingham University Pump Priming Grant (2014-2015) for “Targeting Epigenetics for Cancer Therapy Invasive Lobular Carcinoma of Breast” (Co-investigator - RM20,000.00)
  • Malaysian Toray Science Foundation (MTSF) – Science and Technology Research Grant (2011-2012) for “Synthesis, Biological evaluation and structure activity relationship studies on shogaol analogues as new class of compounds targeting peroxisome proliferator activated receptor gamma (PPARg)” (Principle Investigator – RM 20,000.00)

Supervision of Postgraduates (MSc/PhD)

  • Ms Tham Shiau Ying (PhD Candidate). Notthingham University (Malaysia) 2015-present, Co-supervisor.
  • Mr. Wong Li Zhe (PhD Candidate), IMU (Malaysia) 2016-present, Co-supervisor
  • Ms Aruna Das Athyala (Master in Molecular Medicine Candidate), IMU (Malaysia), 2017-present, Co-supervisor
  • Mr. Ten Yi Yang (PhD Candidate), IMU (Malaysia) 2017-present, Co-supervisor

 

Professional affiliations:

International

Royal Society of Chemistry, United Kingdom Member
Asia Young Pharmacist Group (AYPG) Member
European Association for Cancer Research Member / Ambassador
Taiwan Tzu Chi International Medical Association (TIMA) Member

 

National

Academy of Pharmacy, Malaysia Member
Malaysian Pharmaceutical Society-Young Pharmacist Chapter (MPS-YPC) Deputy Chairperson
Malaysian Pharmaceutical Society Life Member
Young Scientists Network-Academy of Sciences Malaysia Member

 

Academic Awards:

  • 2016 Our research team won The Best Oral Presenter at the International Medical University Undergraduate Research Symposium, 5 November 2016, Kuala Lumpur, Malaysia.
  • 2016 Southeast Asia-European Union-NET II (SEA-EU-NET II) Fellowship, one of the 6 fully sponsored participants from Southeast Asia to join this fellowship programme at the University of Liverpool (United Kingdom) and Chulalongkorn University (Thailand). The project is funded by European Union’s Seventh Framework Programme for research, technological development and demonstration (Grant Agreement : 311784).
  • 2016 First awardee of 2016 Research Mobility Grant, which is jointly supported by Biochemical Society (United Kingdom), British Pharmacological Society (United Kingdom), Royal Society of Biology (Unite Kingdom) and Royal Society of Chemistry (United Kingdom). The grant supports the Visiting Researcher position at Institute of Protein Biochemistry, National Research Council, Naples, Italy.
  • 2015 The research team won the International Medical University (IMU) Achievement Award 2015 under the category of Research and Publications (Research Team).
  • 2015 Sultan Mizan Antarctic Research Foundation (YPASM) Research Fellow, British Antarctic Survey, Cambridge, United Kingdom.
  • 2015 Travel scholarship for “Workshop: Researcher Mobility in Drug Discovery” by Royal Society, AstraZeneca and Drug Metabolism Discussion Group at Milton Keynes, United Kingdom (7-8 December 2015)
  • 2015 Our CSR team won the PhAMA President’s Community Impact & Awareness Award 2015, a deworming project with Kampung Ulu Tual, Pos Sinderut, Pahang; a collaboration between Malaysian Pharmaceutical Society-Young Pharmacists Chapter, Center for Orang Asli Concerns (COAC), and IMU Strathclyde MPharm program Alumni (USAM).
  • 2015 Our research team won The Best Poster of Pharmacology at the Malaysian Pharmaceutical Society Pharmacy Scientific Conference (MPS-PSC) 2015. Kuala Lumpur, Malaysia.
  • 2015 Best Oral Presentation for Free Paper (Personal and Professional Development) by International Medical Education Conference (IMEC) 2015, Kuala Lumpur, Malaysia.
  • 2014 Our research team won the Y.S.P. SAH Best Research Paper Award by Tien Te Lee Biomedical Foundation (Taiwan) for the research paper : 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor?(PPAR?) .Cancer Lett. 2013; 336 (1) : 127–139.
  • 2012 IMU Young Alumnus Award by International Medical University (IMU) to recognise IMU alumni who have made noteworthy contributions to community and society with significant personal and professional achievement.
  • 2012 Best Oral Presenter at the 1st International Nutraceutical and Cosmetic Sciences (ICNaCS). 22-23 October 2012, Kuala Lumpur, Malaysia.
  • 2012 Registration Fees Waiver Scholarship for the 1st International Nutraceutical and Cosmetic Sciences (ICNaCS). 22-23 October 2012, Kuala Lumpur, Malaysia.
  • 2012 Our research team won The Best Poster of Pharmaceutical Chemistry/ Pharmacology/ Traditional and Complementary Medicine at the Malaysian Pharmaceutical Society Pharmacy Scientific Conference (MPS-PSC) 2012. Kuala Lumpur, Malaysia.
  • 2011 Best Poster of Pharmaceutical Chemistry in the Malaysian Pharmaceutical Society Pharmacy Scientific Conference (MPS-PSC) 2011. Kuala Lumpur, Malaysia.
  • 2009 Dean’s List for being high academic achievement in the graduating class for the degree of Bachelor of Pharmacy (Hons) in the International Medical University, Malaysia.
  • 2009 Sanofi-Aventis Award for being excellence in research in the graduating class for the degree of Bachelor of Pharmacy (Hons) in the International Medical University, Malaysia.
  • 2009 Kotra Pharma Award for being excellence in pharmaceutical technology in the graduating class for the degree of Bachelor of Pharmacy (Hons) in the International Medical University, Malaysia.

Recent publications 
(Last 5 years – 2012-2017)

Journal

  • Amjad Ayad Qatran Al-Khdhairawi, Premanand Krishnan, Chun-Wai Mai, Felicia Fei-Lei Chung, Chee-On Leong, Yun-Yee Low, Toh-Seok Kam, Kien-Thai Yong, and Kuan-Hon Lim. A Bis-benzopyrroloisoquinoline Alkaloid Incorporating a Cyclobutane Core and a Chlorophenanthroindolizidine Alkaloid with Cytotoxic Activity from Ficus fistulosa var. tengerensis. Journal of Natural Product (in press) (IF: 3.281, Tier 1: Drug Discovery)
  • Keng Yoon Yeong, Soo Choon Tan, Chun-Wai Mai, Chee-Onn Leong, Felicia Fei-Lei Chung, Yean Kee Lee, Chin Fei Chee, Noorsaadah Abdul Rahman. Contrasting sirtuin and PARP activity of selected 2,4,6-trisubstituted benzimidazoles. Chemical Biology & Drug Design (in press). (IF : 2.396; Tier 2: Biochemistry)
  • You Sheng Chong, Chun Wai Mai, Chee Onn Leong, Lai Chun Wong. Lutein and zeaxanthin reduces cytotoxicity and Alu RNA accumulation in hydrogen peroxide challenged retinal pigment epithelial. Cutaneous and Ocular Toxicology (2017) (in-press) (IF : 1.12; Tier 3: Toxicology)
  • Felicia Fei-Lei Chung, Perry Tan, Vijay Joseph Raja, Boon Shing Tan, Kuan-Hon Lim, Toh-Seok Kam, Ling-Wei Hii, Si Hoey Tan, Sze-Jia See, Yuen-Fen Tan, Li Zhe Wong, Wai Keat Yam, Chun Wai Mai, Tracey D. Bradshaw, Chee-Onn Leong. Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1). Scientific Reports (2017) ( in-press) (IF : 5.228; Tier 1: Multidisciplinary)
  • Hsien Chuen Soo, Felicia Fei-Lei Chung, Kuan-Hon Lim, Veronica Alicia Yap, Tracey D. Bradshaw, Ling-Wei Hii, Si Hoey Tan, Sze Jia See, Yuen Fen Tan, Chee-Onn Leong, Chun-Wai Mai*. Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-kinase (PI3K)-AKT Pathway. PLoS ONE (2017) (in-press) (IF: 3.234; Tier 1: Medicine (Miscellaneous)
  • Chun Wai Mai, Felicia Fei-Lei Chung, Chee-Onn Leong. Targeting legumain as a novel therapeutic strategy in cancers. Current Drug Targets 2017(in press) (IF:3.522 ; Tier 1: Drug Discovery)
  • John Jeh Lung Tiong, Loo Jason, Chun Wai Mai. Global antimicrobial stewardship: A closer look at the formidable implementation challenges. Frontiers in Microbiology 2016 (accepted) (IF: 4.165; Tier 1: Microbiology)
  • Chan Kiang Lim, Subramaniam Hemaroopini, Shu Ying Gan, Siew Mian Loo, Jo Ring Loo, Vivien Yi Mian Jong, Hsien Chuen Soo, Chee Onn Leong, Chun Wai Mai, Chin Fei Chee. In vitro cytotoxic activity of chemical constituents from Malaysia Calophyllum species. Medicinal Chemistry Research 2016 (accepted, in press) (IF: 1.436 ; Tier 1 : Pharmacology, Toxicology and Pharmaceutics)
  • Chun Wai Mai, Kok Seng Ivan Yap, Mee Teck Kho, Nor Hadiani Ismail, Khatijah Yusoff, Khozirah Shaari, Swee Yee Chin, Erin Swee Hua Lim. Mechanisms underlying the anti-inflammatory effects of Clinacanthus nutans Lindau extracts: inhibition of cytokine production and Toll-like receptor-4 activation. Frontiers in Pharmacology 2016; 7:7 (IF: 4.418; Tier 1: Pharmacology)
  • Felicia Fei-Lei Chung, Chun Wai Mai, Pei Yuen Ng, Chee-Onn Leong. Roles of cytochrome P450 2W1 (CYP2W1) in colorectal cancers. Current Cancer Drug Targets 2016;16(1):71-8 (IF: 3.707; Tier 1: Pharmacology; Drug Discovery)
  • John Jeh Lung Tiong, Chun Wai Mai, Pou Wee Gan, Vivienne Sook Li Mak, James Johnson. Separation of prescribing and dispensing in Malaysia: The history, necessities and challenges. International Journal of Pharmacy Practice 2016 (in press) (IF: N/A; Tier 1: Pharmacy)
  • John Jeh Lung Tiong, Chun Wai Mai, Audrey Yong. Academic integrity of healthcare educators – Requisite for nurturing professionalism. Medical Education. 2015(49):1060-1062 (IF: 3.369; Tier 1: Education; Medicine)
  • Chun Wai Mai, Ramadas Anitha, John Jeh Lung Tiong, Pei Kuan Lai, Mallikarjuna Rao Pichika, Alexander Irvine Gray. Chemistry Content in the Pharmacy Curriculum: Relevance to Develop Pharmacists Fit-to-work in Diverse Pharmacy Profession Sectors. Indian Journal of Pharmaceutical Education and Research. 2015; 49(4):240-247 (IF: 0.219 ; Tier 2 : Pharmacology, Toxicology and Pharmaceutics (miscellaneous))
  • Chun Wai Mai, Marzieh Yaeghoobi, Noorsaadah Abd-Rahman, Yew Beng Kang, Mallikarjuna Rao Pichika. Chalcones with electron-withdrawing and electron-donating substituents: Anticancer activity against TRAIL resistant cancer cells, structure-activity relationship analysis and regulation of apoptotic proteins. European Journal of Medicinal Chemistry 2014: 77:378-87 (IF: 3.902 ; Tier 1 : Drug Discovery)
  • Polly Soo Xi Yap, Yik Tse Esther Chong, Yin Yau Wong, Xin Yee Lim, Jia Hui Ang, Heather Su Ling Goh, Mei Xuan Stephanie Lai, Chun Wai Mai, Ayuba Sunday Buru, Mallikarjuna Rao Pichika, Swee Hua Erin Lim. Antibacterial and antifungal testing of the different extracts of Dillenia obovata (Blume) Hoogl. World Journal of Pharmacy and Pharmaceutical Sciences. 2013; 2 (5): 3946-62 (IF: N/A; Tier: N/A)
  • Chun Wai Mai, Yew Beng Kang, Mallikarjuna Rao Pichika. Should a Toll-like receptor 4 (TLR-4) agonist or antagonist be designed to treat cancer? TLR-4: It’s expression and effects in ten most common cancers. Oncotargets and Therapy; 2013;6:1573-87 (IF: 2.272 ; Tier 1: Pharmacology)
  • Syed Shahzad Hasan, Pei Se Wong, Syed Imran Ahmed, David Weng Kwai Chong, Chun Wai Mai, Peter Pook, Therese Kairuz. Perceived Impact of Clinical Placements on Students Preparedness to Provide Patient-Centered Care in Malaysia. Currents in Pharmacy Teaching and Learning July 2013; 5(4): 303-10 (IF: N/A; Tier 2: Pharmacy)
  • Boon Shing Tan, Owen Kang, Chun Wai Mai, Kai Hung Tiong, Alan Soo-Beng Khoo, Mallikarjuna Rao Pichika, Tracey D. Bradshaw and Chee-Onn Leong. 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor ? (PPAR?). Cancer Letters Aug 9 2013;336(1):127-139. . (IF: 5.992 ; Tier 1 : Cancer Research)
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