August 28, 2017 Ebenezer, Chitra

Designation/Title : Senior Lecturer / Dr
Department: Applied Biomedical Science and Biotechnology Division,
International Medical University, Kuala Lumpur
Tel: 03-27317519 
E-mail: Ebenezer_chitra@imu.edu.my

Education and Training

Post-doctoral fellow NHRI, Taiwan -
M.Sc. (Biotechnology) TNAU, India 1997
Ph.D. (Immunology) JNU, India 2005
B.Sc. Agri TNAU, India 1995

 

Research interests:

  • Cancer Biology
  • Molecular Biology
  • Immunology

Research projects/grants:

2017

  • Sensitivity of normal and cancer human cell lines to chitosan-propolis nanoformulation. . Supervisor IMU. RM 3000

2016

  • Evaluation on the effect of Morin on H9C2 cells against oxidative stress and its mechanism of action. Co-supervisor IMU. RM 12000
  • Evaluation of effect of pre-treatment and co-administration of ellagic acid against doxorubicin induced toxicity in H9C2 cardiomyoblast cell line. Supervisor IMU. RM 12000

2015

  • The effect of propolis on mixed biofilm formation by Staphyllococcus aureus with Staphylococcus epidermidids or Pseudomonas aeruginosa. Supervisor IMU. RM 4500

2014

  • Evaluation of the mechanism of action of lactoferricin B peptide in the inhibition of breast cancer. Fundamental Research Grant Scheme (FRGS), Malaysia. Principal Investigator, RM: 165440

2013

  • Development of Novel Chitosan-flavonoids (Propolis Ethanolic Extract) Nanoformulations against Enterococcus Faecalis in the root canal using extracted human tooth model. Co-investigator, Elementary Research Grant Scheme, Malaysia. RM: 221000
  • Post-translational regulation of glutamine metabolism by acetylases and deacetylases in cancer cells under hypoxic conditions. Fundamental Research Grant Scheme (FRGS), Malaysia. Co-investigator, RM: 151650.
  • Effect of madecassoside in reducing oxidative stress and blood glucose and in protecting the ?-cells in streptozotocin-nicotinamide induced diabetes in rats. Fundamental Research Grant Scheme (FRGS), Malaysia. Co-investigator, RM: 135000

Supervision of Postgraduates (MSc/PhD)

  • Ong Teik Hwa Development of novel chitosan nanoformulations against biofilm formed by E. faecalis M.Sc. IMU 2014-16

Professional affiliations:

  • Indian Immunology Association Member

Academic Awards:

  • ICAR Junior Research Fellowship - M.Sc. (1995-1997)
  • National Eligibility Test (NET) for lectureship (1999)
  • The Governor’s prize for the best B.Sc. (Ag) student of TNAU (1994)

Recent publications
(last 5 years – 2012 -2017)

  • Ong TH, Chitra E, Ramamurthy S, Siddalingam RP, Yuen KH, Ambu SP, Davamani F. Chitosan-propolis nanoparticle formulation demonstrates anti-bacterial activity against Enterococcus faecalis biofilms. PLoS One. 2017 Mar 31;12(3):e0174888.
  • Gund R, Balyan R, Ebenezer C, Khalsa JK, Verghese DA, Krishnamurthy T, George A, Bal V, Rath S, Chaudhry A. Modulation of naïve CD8 T cell response features by ligand density, affinity and continued signaling via internalized TCRs. J Immunol. 2017 Mar;198(5):1823-1837.
  • Shao HY, Huang JY, Lin YW, Yu SL, Chitra E, Chang CK, Sung WC, Chong P, Chow YH. Depletion of Treg cells leads to moderate B cell antigenicity in RSV infection. Int J Infect Dis. 2015 Dec;41:56-64.
  • Yueh-Liang Tsou, Yi-Wen Lin, Hsuen-Wen Chang, Hsiang-Yin Lin, Hsiao-Yun Shao, Shu-Ling Yu, Chia-Chyi Liu, Ebenezer Chitra, Charles Sia, Yen-Hung Chow. Heat Shock protein 90: Role in Enterovirus 71 Entry and Assembly and Potential Target for Therapy. PLoS One 2013; 8(10):e77133. IF: 4.4
  • Yi-Wen Lin, Shu-Ling Yu, Hsiao-Yun Shao, Hsiang-Yin Lin, Chia-Chyi Liu, Kuang-Nan Hsiao, Ebenezer Chitra, Tsou YL, Chang HW, Charles Sia, Pele Chong, Yen-Hung Chow. Human SCARB2 Transgenic Mice as an Infectious Animal Model for Enterovirus 71. PLoS One 2013, 8(2):e57591. IF: 4.4
  • Yi-Wen Lin, Hsiang-Yin Lin, Yueh-Liang Tsou, Ebenezer Chitra, Kuang-Nan Hsiao, Hsiao-Yun Shao, Chia-Chyi Liu, Charles Sia, Pele Chong, Yen-Hung Chow. Human SCARB2-mediated entry and endocytosis of EV71. PLoS One, 2012, 7(1):e30507. IF: 4.4
  • Rupali Gund, Ebenezer Chitra, Krishnamurthy Thyagarajan, Ashutosh Chaudhry, Anna George, Vineeta Bal, and Satyajit Rath. Antigenic ligand density modulates execution of naïve CD8+ T cell response programme. J Immunol. 2012, 188, 110.1 IF: 5.788
2018-01-09T06:19:59+00:00