August 29, 2017 Ing Hong, Ooi

Designation/Title : Associate Professor
Department: Pharmaceutical Chemistry
Tel: 03-2731 7275
Fax: 03-8656 7229
E-mail :

Education and Training

PhD University of Akron, Ohio, USA, 1998
MSc University of Malaya, 1980
BSc University of Malaya, 1986


Research interests:

  • Biocompatible and biodegradable polymers based nanoparticulate drug carriers
  • Biomaterials design and development (Gold nanoparticles, Stimuli-responsive hydrogels, Fluoride-releasing Dental restorative materials, etc)
  • Research involving instrumental analyses using NMR (13C, 1H, 19F), FTIR, UV-Vis spectrophotometer, HPLC, LCMS, Head-space GCMS, ICP-MS, SIMS, Zetasizer, FE-SEM, TEM, ESCA, DSC, TGA, DMA, AFM.

Research projects/grants:

  • A novel strategy to overcome endosomal degradation of gene therapeutics, MOHE-FRGS, RM 133,000.00; 2016-2017; Principal Investigator
  • Investigation on the mechanomutable properties of a biosourced polymer: Ceiba Pentandra, MOHE-FRGS, RM 101,000.00; 2016-2017; Co-Principal Investigator
  • Investigation of Bioavailability and Pharmacokinetics of Tocotrienol in Healthy Subjects Supplemented with Different Commercial Formulations, Contract Research, RM131,222.00; Jul-Dec 2016 ; Co-Principal investigator
  • Hit to Lead Optimisation: Synthesis and Biological Evaluation of New Thienopyrimidine Derivatives as Potential Antagonists of Adenosine A3 Receptor, A Promising Target for The Treatment of Asthma, MOSTI eSci; RM80,000.00; 2015 -2017;   Co-Principal investigator
  • Synthesis, Characterisation and Evaluation of Amphiphilic Star-branched Folate-Terminated PLA-(PEG)2 Block Copolymers as Nanocarriers for Targeted Drug Delivery, MOSTI-eSci, RM241,000.00, 2013-2016 – Principal investigator
  • Star-Shaped Copolymer Poly (Lactide-Co-Glycolide)-b-(Monomethoxy Poly(Ethylene Glycol))2 as Nanocarriers for Drug Delivery: Synthesis, Characterisation, and In Vitro Drug Release Study, MOHE-FRGS, RM70,000.00, 2013-2015, Principal investigator
  • Fluoride-containing monomethacrylate reactive diluent monomers for dental restoration: synthesis, formulation and characterization / IMU (2011- 2012) – Principal Researcher
  • Novel AuNP-{linker-[Zn(II)(FL-ligand)(aa)x] (NO3)m}n Conjugates: Synthesis, Characterization and Factors Affecting their Properties, MOHE-FRGS, RM135,000.00, 2015-2017, Co-Investigator
  • Development of Ternary Copper(II) Complexes as Effective and Selective Anticancer Drugs via ROS-induction and/or Proteasome Inhibition, MOSTI-eSci, RM279,000.00, 2013-2015, Co-Investigator
  • Systemic delivery of siRNA-based therapeutics using functionalized single-walled carbon nanotubes (SWNTs),’ under the top-down nanotechnology funding, MOHE, 2011-2014 – Co-researcher
  • Potential anti-Alzheimer’s activity of brown algae metabolites, eScience Funding from MOSTI for the years (2012-2013) – Co-researcher
  • Development of Temozolomide Loaded Poly(Lactic-Co-Glycolic Acid)  Nanoparticulate Carriers for Targeted Delivery to Glioblastoma Cells/ Univ. Monash Sunway (2012-2014) – Co-researcher
  • Synthesis and Thermoresponsive Property of PNIPAAm  Methacrylic-Ferulic acid copolymer Hydrogels for Biomedical Applications/ BPharm Semester-7 student projects (2012)/ IMU – Principal researcher

Supervision of Postgraduates (MSc/PhD)
(Last 5 years – 2012-2017)

  • 5 MSc students


Professional affiliations:

  • Member of the American Chemical Society (ACS)
  • Member of the Royal Society of Chemistry (MRSC)
  • Member of the Malaysian Institute of Chemistry (AMIC)

Academic Awards:

  • Achievement Award for development of new programme -MSc in Analytical and Pharmaceutical Chemistry (MAPC)

Recent publications 
(last 5 years – 2012 -2017)

  • Lee CY, Ooi IH. Preparation of Temozolomide-Loaded Nanoparticles for Glioblastoma Multiforme Targeting-Ideal Versus Reality, Pharmaceuticals 2016; 9(3), 54; doi: 10.3390/ph9030054 (Open Access) [Q1; IF 4.5]
  • Low ML, Cheang WC, Ng PY, Ooi IH, Maah MJ, Chye SM, Ng SW, Tan KW, Ng CW. Ternary and binary copper(II) complexes: synthesis, characterization, ROS-inductive, proteasome inhibitory and anticancer properties, Journal of Coordination chemistry, 2016, accepted [Q2; IF 1.79]
  • Tan SY, Wong MM, Tiew ALW, Choo YW, Lim SH, Ooi IH, Modamio P, Fernández C, Mariño EL, Segarra I. Sunitinib DDI with paracetamol, diclofenac, mefenamic acid and ibuprofen shows sex-divergent effects on the tissue uptake and distribution pattern of sunitinib in mice. 2016 Aug 5 published online, Cancer Chemother Pharmacol 1-10. Doi:10.1007/s00280-016-3120-9 [Q1; 2.97]
  • Chan CW, Lai JW, Ooi IH, Er HM, Chye SM, Tan KW, Ng SW, Maah MJ, Ng CH.  
    Structural characterization, ROS-inductive and proteasome inhibitory properties of 
    ternary and binary copper(II) complexes of N2-and N2O2-ligands. Inorganica Chimica Acta, 2016; 450: 202-210. [Q2; IF 2.01]
  • Ng CH, Wang WS, Win YF, Neo K, Ganguly R, Er HM, Ooi IH. rac-Aqua(4-methyl-oxazolidine-4-carboxylato)(nitrato)(1,10-phenanthroline)copper(II), the aldol condensation product of formaldehyde with the D- and L-(alaninato)aqua(1,10-phenanthroline)copper(II) nitrate. Transition Metal Chemistry, 2016; 41(4): 365-488 ???. [Q3; IF 1.32]
  • Ng CH, Chan CW, Lai JW, Ooi IH, Chong KV, Maah MJ, Seng HL. Enantiomeric pair of copper(II) polypyridyl-alanine complexes: effect of chirality on their interaction with biomolecules. Journal of Inorganic Biochemistry,2016; 160: 1-11. [Q1; 3.38]
  • Lai JW, Chan CW, Ng CH, Ooi IH, Tan KW, Maah MJ, Ng SW. Hydrated and anhydrous forms of copper(II) complex of 3-methylpicolinic acid, and spectroscopic studies of their ROS-inducing and proteasome inhibition. Journal of Molecular Structure, 2016; 1106: 234-241. [Q3; IF 1.58]
  • Junaid A, Deb PK, Ooi IH, El-Rabie D, Shuiab FO, Rajasingam R. Design, Synthesis and Pharmacological Properties Peptidomimetics: A Review. Asian Journal of Chemistry, 2015; 27(9): 3137-3142. {Q3; IF 0.38]
  • Ooi IH, NG SH. Swelling Properties of Poly(N-isopropylacrylamide)/Calcium Alginate Interpenetrating Polymer Network Hydrogel containing Zirconia. Asian Journal of Chemistry, 2015; 27(9): 3489-3493. [Q3; IF 0.38]
  • Ooi IH, Ng SH. Effects of Microemulsion Conditions on Drug Encapsulation Efficiency of Salicylic Acid in PLGA Microparticles. Asian Journal of Chemistry, 2015;  27(4): 1358-1360. [Q3; IF 0,38]