August 28, 2017 Chee Onn, Leong

Designation/Title : Associate Professor
Department: School of Pha
Tel: 03-2731 7528
Mobile : 012 208 5170
Fax : 03-8656 7229
E-mail : cheeonn_leong@imu.edu.my
Education and Training
Associate Professor | International Medical University (IMU) | Present |
Senior Lecturer | International Medical University (IMU) | 2001 |
Research Fellow | Harvard Medical School, Boston, USA | 2008 |
PhD | University of Nottingham, UK | 2003 |
BSc | University Putra Malaysia | 2000 |
Research interests:
- Cancer Biology
- Drug Discovery and Development
- Molecular Cancer Therapeutics
- Signal Transduction, Epigenetics
Research projects/grants:
- Systemic delivery of siRNA-based therapeutics using functionalized single-walled carbon nanotubes (SWNTs)
MOSTI Nanotechnology Fund, Malaysia (Principal Investigator) - The Role of BCL2 Family Proteins in Mutant p53 “Gain of Function”
MoHE FRGS,Malaysia (Principal Investigator) - Molecular target and mechanism of action of F8268, a novel and potent antitumor compound isolated from an endophytic Aspergillus.
MoHE FRGS, Malaysia (Co-investigator) - Rapid identification of new molecular targets for treatment of refractory breast cancers
MOSTI eScience Fund, Malaysia (Principal Investigator) - Targeting mutant p53 for treatment of basal-like breast cancers
MAKNA Cancer Research Award, Malaysia (Principal Investigator) - Novel regulatory mechanisms for p53-independent apoptosis in tumor cells
ECOR Fund for Medical Discovery, USA (Principal Investigator)
Supervision of Postgraduates (MSc/PhD)
(Last 5 years – 2012-2017)
- Mr Tan Boon Shing – PhD. (2012 - Present) - Chief Supervisor
Role of mutant p53 in cellular anoikis. - Ms Tiong Kai Hung – PhD. (2010 - Present) - Chief Supervisor
Identification of new molecular targets for treatment of basal-like breast cancers. - Mr Choo Heng Lungh – PhD. (2010 - Present) - Chief Supervisor
Targeting the human kinome in nasopharyngeal carcinomas. - Ms Ong Li Chu – MSc. (2011 - Present) - Chief Supervisor
Nanotoxicity of Pristine and Functionalized Single-Wall Carbon Nanotubes (SWNTs) - Mr Tan Boon Shing – MSc. (2010 - 2012) - Chief Supervisor
Mechanism of mutant p53 gain-of-function effects in human breast cancers - Ms Nor Nadia Ban – MSc. (UiTM, 2010 - present) – Co-Supervisor
Molecular target and mechanism of action of F8268, a novel and potent antitumor compound isolated from an endophytic Aspergillus.
Professional affiliations:
- British Association for Cancer Research (Member)
- European Association for Cancer Research (Member)
- American Association for Cancer Research (Associate Member)
- Malaysian Society for Molecular Biology and Biotechnology (Member)
- Malaysian Society of Nasopharyngeal Carcinoma (Member)
Academic Awards:
- 10th International Conference of the Asian Clinical Oncology Society (ACOS) Travel Award, Korea
- MAKNA Cancer Research Award (Malaysia)
- Best presentation award (3rd Regional Conference on Molecular Medicine 2009, Malaysia)
- ECOR Fund for Medical Discovery Fellowship Award (USA)
- Best poster and oral presentation award (4th Annual Symposium of the Dana-Farber/Harvard Cancer Center Program in Breast Cancer, Boston, USA).
- Best poster presentation award (Annual Scientific Advisory Board Meeting for Cancer Research, USA)
- Overseas Research Student Awards Scheme (ORS) - University of Nottingham, UK
- International Biomedical Society Young Scientist Award - Institute of Biomedical Sciences, UK
- Best Student of the Year - Roche Inc.
- Best Academic Achievement (Pharmacology) – Pfizer
- Best Academic Achievement (Human Physiology)
- Best Academic Achievement (Human Nutrition)
Recent publications
(Last 5 years – 2012-2017)
Journal
- Low SY, Tan BS, Choo HL, Tiong KH, Khoo AS, Leong CO: Suppression of BCL-2 synergizes cisplatin sensitivity in nasopharyngeal carcinoma cells. Cancer Lett 2012, 314(2):166-175. (IF = 4.864)