October 31, 2021 Mohd Zulkefeli bin Mat Jusoh

Designation/Title: Assoc. Prof. Dr.
Department: School of Pharmacy, International Medical University
Tel: 03-2731 7313
E-mail: [email protected]

Education and Training

Post-Doctoral Fellow for Foreign Scientist JSPS (Japan Society for Promotion of Sciences)  Tokyo University of Science 2010
MDS University of Kerala, India 2012
Doctor of Philosophy (Pharmaceutical Science) Hiroshima University, Japan 2005
Masters (Molecular Science Pharmacy), Hiroshima University, Japan 2002
B.Pharm. Sc. Hiroshima University, Japan 1998

Research interests:

  • Supramolecular Chemistry – Design and Synthesis of Functionalities Supramolecules by Self-Assembly method in Aqueous Solution.
  • Medicinal Chemistry – Design and Synthesis of Small Molecules and Metal Complexes Molecules with Deoxyribonucleic Acid Recognition and Therapeutic Property.
  • Co-Formulation of Polymers with Drugs and Nutraceuticals.
  • Pharmacy, Pharmaceutical Sciences and STEM Education.

Research projects/grants:
National Research & Development Grants

  1. MAKNA (National Cancer Council) Cancer Research (Jan 2006 – Dec 2007) – RM 30,000.00 (Principal Researcher).
  2. MOSTI (Initiative R&D) with Institute of Pharmaceutical Nutraceutical Malaysia (Jan 2007 – Dec 2009) – RM 1,160,000.00 (Principal Researcher).
  3. Japan Society for the Promotion of Science (JSPS) (Nov 2008–Oct 2010) – JPY 160,000.00 (Post Doctoral Fellow).
  4. Exploratory Research Grant Scheme (ERGS) (Jan 2011 – Dec 2013) – RM 95,000.00 (Co-Researcher).
  5. Research Acculturation Collaborative Effort (RACE) (Jan 2013 – Dec 2014) – RM 50,000.00 (Co-Researcher).
  6. Research Intensive Faculty (RIF) (Jan 2013 – Dec 2014) – RM 32,000.00 (Principal Researcher).
  7. Fundamental Research Grant Scheme (FRGS 1/2014) (July 2014 – June 2017) – RM 128,800.00 (Principal Researcher).
  8. Fundamental Research Grant Scheme (FRGS 2/2014) (Dec 2014 – Nov 2016) – RM 130,000.00 (Co-Researcher).
  9. University of Malaya Research Grant (UMRG 2015) (June 2015 – June 2016) – RM 71,600.00 (Co-Researcher).
  10. Fundamental Research Grant Scheme (FRGS 1/2015) (Nov 2015 – Nov 2017) – RM 140,200.00 (Co-Researcher).
  11. Institute of Islamic Understanding Malaysia (IKIM) Research Fund (July 2018 – July 2019) – RM 30,000.00 (Co-Researcher).
  12. The Pancreatic Cancer Challenge Grant (IMU) (Mar 2019 – Feb 2020) – RM 50,000.00 (Co-Researcher)
  13. Research grant for IMU BPharm Semester 7 project (Ms. Ng Yee Min, Ms Kuan Hui En, Title: Development of Convenient Methods for Detection and Capture of Circulating Tumor Cells, Research Project ID: BP I-02/15(68)2017 (Dec 2017 – May 2018) RM 6,000.00 (A/P Dr Mohd Zulkefeli (Principal Investigator), Prof. Shin Aoki (Tokyo University of Science) and Prof. Mallikarjuna Rao Pichika (IMU))
  14. Research grant for IMU BPharm Semester 7 project (Ms. How Chiu Her (00000022833), Ms. Chai Ming Yeh (00000022917), Title: Development of Convenient Methods for Detection and Capture of Circulating Tumor Cells, Research Project ID: BP I-01/2019(47) (Aug 2019 – Dec 2019) RM 6,000.00 (A/P Dr Mohd Zulkefeli (Principal Investigator), Prof. Shin Aoki (Tokyo University of Science) and Prof. Mallikarjuna Rao Pichika (IMU))
  15. Research grant for IMU BPharm Semester 7 project (Ms. Michelle Yeong Zi Yin (00000024236), Mr. Saw Yan Bin (00000017660), Title: Analysis on The Role of Atypical Protein Kinase C (aPKC) in Cancer Stem Cells, Research Project ID: BP I-01/2019(48) (Aug 2019 – Dec 2019) RM 6,000.00 (A/P Dr Mohd Zulkefeli (Principal Investigator), Prof. Shin Aoki (Tokyo University of Science) and Prof. Mallikarjuna Rao Pichika (IMU))
  16. Research grant for IMU BPharm Semester 7 project (Ms. Nur Aina binti Azhar; Ms. Hazimah Syazwani binti Samsul Kamar), Title: In vitro Anti-inflammatory Activity of 4,4'-(alk-1,5-diylbis(oxy))dibenzimidamides and Their Zinc Complexes Analogue, Research Project ID: : BP I-2020(03) (July 2020 – Dec 2020) RM 6,000.00 (A/P Dr Mohd Zulkefeli (Principal Investigator), Prof. Mallikarjuna Rao Pichika (IMU) and Ms. Mak Kit Kay (IMU))

Supervision of Postgraduates (MSc/PhD)
(Last 5 years – 2016-2021)

  1. Mak Kit Kay (PhD Medical & Health Sciences, International Medical University) 2019-current “Integration of Artificial intelligence (AI) and Computer Aided Drug Discovery (CADD) techniques for the development of novel drug-like Keap1-Nrf2 inhibitors/direct Nrf2 activator” – Co-Supervisor.
  2. Liew Hui Shan (Vanessa) (MSc Medical & Health Sciences, International Medical University) 2019-2021 “Novel gemcitabine – Re(I) tricarbonyl complexes combinations, conjugates and formulations with liquid crystalline nanoparticles for pancreatic cancer photodynamic therapy and bioimaging”-Co-Supervisor.
  3. Geetha A/P Maniam (MSc Medical & Health Sciences, International Medical University) 2017-2020 “Preparation, characterisation and anticancer effects of gemcitabine-tocotrienols entrapped niosomes in pancreatic cancer”-Co-Supervisor.
  4. Nor Amin Bin Hassan (MSc PH780 Universiti Teknologi MARA) 2011-2018 “Design and Synthesis of Ortho, Metha, Para Methylphenylguanidinium-Zn2+-Cyclen Complex and its Reaction Towards Nucleic Acid”-Supervisor.

Professional affiliations

  1. Malaysian Pharmaceutical Society (Member, membership no.S3040)
  2. American Chemical Society (ACS) (Regular member since 2018, membership no.31576003), Local Chapter Advisor
  3. Malaysian Academy of Pharmacy (MAP) (Assistant Principal 2018-2019) (Principal 2019-2021)
  4. Member of Pharmacy Board Malaysia (2019-2022)

Recent publications
(last 5 years – 2016-2021)

  1. Chew Hee Ng, Thean Heng Tan, Ngee Heng Tioh, Hoi Ling Seng, Munirah Ahmad, Seik Weng Ng, Wei Khang Gan, May Lee Low, Jing Wei Lai and Mohd Zulkefeli: Synthesis, Characterization and Multiple Targeting with Selectivity: Anticancer Property of Ternary Metals Phenanthroline-Maltol Complexes. Journal of Inorganic Biochemistry, 2021 (accepted)
  2. Geetha Maniam, Chun-Wai Mai, Mohd Zulkefeli and Ju-Yen Fu: Co-Encapsulation of Gemcitabine and Tocotrienols in Nanovesicles Enhanced Efficacy in Pancreatic Cancer. Nanomedicine, 2021, 16 (25), (https://doi.org/10.2217/nnm-2020-0374)
  3. Kit-Kay Mak, Zhang Shiming, Madhu Katyayani Balijepalli, Albena T. Dinkova-Kostovae, Ola Epemolu, Zulkefeli Mohd, Mallikarjuna Rao Pichika: Studies on the mechanism of anti-inflammatory action of swietenine, a tetranortriterpenoid isolated from Swietenia macrophylla seeds. Phytomedicine Plus, 2021, 100018. (doi.org/10.1016/j.phyplu.2020.100018)
  4. Mohamad Haniki Nik Mohamed, Vivienne Mak, G Sumalatha, Agung Endro Nugroho, Triana Hertiani, Mohd Zulkefeli, Enkhjargal Dorjbali, Shinezaya Dashbaljir, Erwin Martinez Faller, Christine Aileen Ching Benosa, Syahrir Zaini: Pharmacy education during and beyond COVID-19 in six Asia-Pacific countries: Changes, challenges, and experiences. Pharmacy Education, 2020, 20(2) 183-195. (doi.org/10.46542/pe.2020.202.183195) (IF 2020 = 0.3)
  5. Hui Shan Liew, Chun-Wai Mai, Mohd Zulkefeli, Thiagarajan Madheswaran, Lik Voon Kiew, Nicolas Delsuc, May Lee Low: Recent Emergence of Rhenium(I) Tricarbonyl Complexes as
    Photosensitisers for Cancer Therapy. Molecules, 2020, 25 (18), 4176.
  6. Rosdi, Atiqurrahman; Azizan, Suzana Ariff; Ilham, Zul; Fujieda, Ayako; Jamil, Asyraf Isyraqi; Shaikh Mohd Saifuddeen; and Zulkefeli, Mohd: A Critical Outlook on the Role of Research Practices in Laboratory towards Student Skills Development in Malaysian and Japanese Public Universities. International Journal of Innovative Research and Advanced Studies, 2020, 7 (4), 16-23. (ISSN 2394-4404)
  7. Mazzura Wan Chik, Zahid Hussain, Mohd Zulkefeli, Minaketan Tripathy, Sunil Kumar, Abu Bakar Abdul Majeed, K. Byrappa: Polymer-wrapped single-walled carbon nanotubes: a transformation toward better applications in healthcare. Drug Delivery and Translational Research, 2019, (9), 578-594; (DOI:10.1007/s13346-018-0505-9) (IF 2018 = 3.094).
  8. Mohd Zulkefeli, Alshakim Nelson, Victoria Piunova and Joseph Sly: Co-Delivery of Cholesterol Lowering Drugs and Nutraceuticals. US Patent US10,457,759, 2019
  9. Geetha Maniam, Chun-Wai Mai, Mohd Zulkefeli, Christine Dufès, Doryn Meam-Yee Tan and Ju-Yen Fu: Challenges and Opportunities of Nanotechnology as Delivery Platform for Tocotrienols in Cancer Therapy. Front. Pharmacol., 2018, 9,1358 (DOI: 10.3389/fphar.2018.01358) (IF 2020 = 1.23) (Web of Science (ISI) Index).
  10. Atiqurrahman Rosdi, Zul Ilham, Suzana Ariff Azizan, Mohd Zulkefeli, Shaikh Mohd Saifuddeen: Relationship Dimension in University Laboratories and Its Effects on Students’ Interest. The European Proceedings of Social & Behavioural Sciences, 2018, 40, 128-141; (DOI:10.15405/epsbs.2018.05.13) (Web of Science WOS Clarivate ISI Conference Proceedings Citation Index (ISI CPCI))
  11. Muhammad Taha, Nor Hadiani Ismail, Waqas Jamil, Syahrul Imran, Fazal Rahim, Syed Muhammad Kashif, and Mohd Zulkefeli: Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives and evaluation of their antiglycation potential. Medicinal Chemistry Research, 2016, 25, 225;(DOI:10.1007/s00044-015-1476-8) (IF 2016 = 1.436) (Web of Science (ISI) Index).
  12. Yosuke Hisamatsu, Yuya Miyazawa, Kakeru Yoneda, Miki Miyauchi, Mohd Zulkefeli and Shin Aoki: Supramolecular Complexes Formed by the Self-assembly of Hydrophobic Bis(Zn2+-cyclen) Complexes, Copper, and Di- or Triimide Units for the Hydrolysis of Phosphate Mono- and Diesters in Two-Phase Solvent Systems (Cyclen=1,4,7,10-Tetraazacyclododecane). Chem. Pharm. Bull., 2016, 64, 451-464;(DOI:10.1248/cpb.c15-01014) (IF 2015 = 1.164) (Web of Science (ISI) Index).
2021-10-31T19:52:40+00:00 31 Oct 2021|Researchers, Uncategorized|Comments Off on Mohd Zulkefeli bin Mat Jusoh