Centre for Bioactive Molecules and Drug Delivery

The Centre for Bioactive Molecules and Drug Delivery (BMDD) consists of experts from diverse disciplines. The main aim of BMDD is to facilitate and support a continuum of research and development activities from the discovery and characterisation of bioactive molecules to clinical trials. The Centre will support opportunities for the commercialisation of Analytical and Pharmaceutical Services (CAPS). BMDD consists of experts in chemistry, formulation science, molecular biology, pharmacology, microbiology, etc.
The expertise in BMDD includes analytical method development and validation of chemicals and active pharmaceutical ingredients in various matrices, design and development of pharmaceutical formulations and cosmetics, and conducting molecular biology, animal, and microbiology experiments to elucidate the molecular mechanisms in bioactivity and toxicity of test compounds. Additionally, BMDD performs in vitro and in vivo pharmacokinetic assays and integrates artificial intelligence and computer-aided drug discovery for the design of novel compounds against given biological targets relevant to any disease. This integration also aids in predicting molecular mechanisms, toxicity, pharmacokinetics, and drug-like properties of compounds.

Purpose

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Preparation and development pharmaceutical formulations & cosmetics
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Drug stability studies in pharmaceutical formulations & cosmetics
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Development and validation of analytical methods
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Trace element analysis in Pharmaceutical formulations, cosmetics, food products & environmental samples
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Method development & validation for preparing the bioactive-enriched extracts
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Design & synthesis of organic compounds and polymers
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Prediction of the bioactivity and mechanisms of organic compounds using computational drug discovery and artificial intelligence technologies
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In vitro & in vivo pharmacokinetics and metabolic stability studies
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In vitro bioassays for determining the bioactivity and mechanism of bioactive compounds in metabolic, inflammatory, neurological & infectious diseases, and cancer
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In vivo assays for determining the efficacy, potency, and safety of the bioactive compounds in experimental animal models for metabolic, inflammatory, neurological & infectious diseases, and cancer

Focus Area

01

Pharmaceutical Formulations & Cosmetics

  • Preparation and development of pharmaceutical formulations and cosmetic and herbal products.
  • Conducting drug stability studies in pharmaceutical formulations, cosmetics and herbal products.

02

Analytical Method Development

  • Development and validation of analytical methods.
  • Trace element analysis in pharmaceutical formulations, cosmetics, food products, and environmental samples.
  • Method development and validation for preparing bioactive-enriched extracts.

03

Chemical Synthesis

  • Design and synthesis of organic compounds and polymers.
  • Prediction of bioactivity and mechanisms of organic compounds using computational drug discovery and artificial intelligence technologies.

04

Pharmacokinetics and Metabolic Studies

  • In vitro and in vivo pharmacokinetics and metabolic stability studies.

05

Bioactivity and Mechanism Assays

  • In vitro bioassays are used to determine the bioactivity and mechanisms of bioactive compounds in metabolic, inflammatory, neurological, and infectious diseases, as well as cancer.
  • In vivo assays are used to determine the efficacy, potency, and safety of bioactive compounds in experimental animal models for metabolic, inflammatory, neurological, and infectious diseases, as well as cancer.

Core Facilities

Drug Discovery
Formulation Development
Analytical Instrumentation
Animal House
Molecular Mechanisms
Microwave Synthesiser
Flash Pressure Liquid Chromatography System

Strategic Plan

Our vision is to increase awareness among researchers about the latest advancements in pharmaceutical, cosmeceutical, analytical, and drug development fields. To achieve this vision, we aim to develop cutting-edge pharmaceutical and cosmeceutical formulations that address industry challenges and elevate technology to the next level. Additionally, we aim to develop robust and reproducible analytical methods to quantify active pharmaceutical ingredients in pharmaceutical and cosmeceutical formulations, as well as major bioactive compounds in natural products.

Our strategic objectives include investigating the molecular mechanisms of compounds of interest using various in vivo, ex vivo, and in vitro studies and determining the DMPK (drug metabolism and pharmacokinetics) properties and pharmacokinetics of these compounds using in vitro, in vivo, and ex vivo models. We also aim to integrate artificial intelligence (AI) and Computer-Aided Drug Design (CADD) technologies to identify new biological targets for diseases of interest and to discover novel or new drug-like compounds targeting these biological targets.

Furthermore, we aim to develop standardised and reproducible methods for the extraction of plant and algae extracts. Research efforts will focus on projects suitable for national, international, and industry research funding bids. We will collaborate with various schools within the International Medical University (IMU) to foster a research culture that produces high-quality publications and innovations, aligning with IMU’s vision of achieving world rankings below 500 (Road to 500). To implement this strategic plan, we will launch targeted campaigns to educate researchers about the latest advancements and encourage the development of advanced formulations, establish dedicated research teams to create robust analytical methods and disseminate findings, incorporate AI and CADD technologies into drug discovery processes to identify novel targets and compounds, standardise and reproduce methods for plant and algae extraction to ensure consistency and quality, and partner with IMU schools to promote a collaborative research environment aimed at producing impactful publications and innovations.

Services Offered

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Expertise / Team

Centre Head

Prof Dr Pichika Mallikarjuna Rao

Professor, Department of Pharmaceutical Chemistry,
School of Pharmacy