Career-Research Positions Vacancy

June 2, 2017 Career-Research Positions Vacancy


Location International Medical University, Bukit Jalil, KL
Position Type Full Time
Duration  3 year

The candidate will have the opportunity to conduct a research on molecular epidemiology in the field of gastric cancer, and to pursue his/her postgraduate degree (PhD by Research).

Main Duties and Responsibilities

  1. To plan, design, set up and conduct the research project, record and analyse the research findings as directed and supervised by the principal investigator
  2. To keep up-to-date with recent literature and advances in the molecular aspect of gastric cancer
  3. To participate in discussion and data review with the supervisory committees
  4. To maintain good research records and documentation
  5. To present research findings at local or international conference(s) or seminar(s)
  6. To publish research findings in indexed peer-reviewed journal(s)
  7. To prepare his/her dissertation for examination

Qualifications and Personal Attributes

  1. Master Degree in Medical Sciences, Health Sciences, Biological or Life Sciences (e.g cell biology, biochemistry, immunology or related area)
  2. Possess problem solving skills
  3. Self-motivated and able to work in team
  4. Possess good interpersonal skills
  5. Good verbal and written scientific communication skills (in English language)

Closing date: 30 April 2019

Interested candidates are required to submit your curriculum vitae to Associate Professor Dr Cho M Naing at cho_naing@imu.edu.my

Project synopsis
In Malaysia, gastric cancer is one of the ten most frequent cancers. Gastric cancer is a multi-factorial disease. The International Agency for Research in Cancer (IARC) has established Helicobacter pylori (H. pylori) infection as a risk factor for gastric cancer. It has been postulated that colonization of H. pylori leads to infiltration of gastric mucosa with inflammatory leading to production of cytokines. Proinflammatory cytokines could contribute to a higher risk of pangastritis, predisposing to gastric metaplasia and eventually to carcinoma. Studies showed that a high prevalence of H. pylori infection does not always result in a high incidence of gastric cancer. Only a small portion of H. pylori infected people have gastric cancer, suggesting that other susceptible factors such as genetic variants may be considered in gastric carcinogenesis. For instance, studied reported that the incidence of gastric cancer in Chinese individuals residing in China represent 42% of the worldwide estimation. In Malaysia, studies have reported that the majority of gastric cancer are the Chinese individuals (66%), followed by the Malays (18.7%) and the Indians (15.3%).
The present study is aimed to investigate the synergistic interaction of gene polymorphisms in the risk of H. pylori infected gastric cancer cases admitted to a Government hospital. The methodology includes a case-control design investigating the H. pylori status and the risk of gastric carcinoma, followed by molecular assessment of inflammatory cytokines and an exploration of the gene-gene interaction, with multi-dimensionary reduction analysis. A research effort directed towards the identification of associations between genetic polymorphism involved in immunity and H. pylori-related gastric cancer has the potential to provide novel insights into targeted treatment in genetically-susceptible individuals. This will improve primary and secondary prevention of H. pylori-related gastric cancer in Malaysia, a disease that remains the one of the top ten cancer in this country.

Methodology

  1. Molecular techniques such as DNA and RNA extraction, PCR, quantitative analysis of gene expressions etc.
  2. Statistical analysis of gene-gene interactions
  3. Genetic factor assessments


Location International Medical University, Bukit Jalil, KL
Position Type Full Time
Duration  1 year

The candidate will have the opportunity to conduct research on environmental health, to critically analyse and publish his/her experimental findings in peer reviewed journal(s), and to pursue his/her postgraduate degree (Master of Science or PhD by Research).

Main Duties and Responsibilities

  1. To plan, design, set up and conduct the research project, record and analyse the research findings as directed and supervised by the principal investigator
  2. To keep up-to-date with recent literature and advances in the field of environmental health
  3. To participate in discussion and data review with the supervisory committees
  4. To maintain good research records and documentation
  5. To present research findings at local or international conference(s) or seminar(s)
  6. To publish research findings in indexed peer-reviewed journal(s)
  7. To prepare his/her dissertation for examination

Qualifications and Personal Attributes

  1. Degree in Medical Sciences, Health Sciences, Biological or Life Sciences such as cell biology, biochemistry, immunology or related area
  2. Possess good analytical and problem solving skills
  3. Self-motivated and able to work in team
  4. Possess good interpersonal skills
  5. Good verbal and written scientific communication skills (in English language)

Closing date: 30 April 2019

Interested candidates are required to submit your curriculum vitae to A/P Dr Wong Shew Fung at shewfung_wong@imu.edu.my.

Project synopsis
Public are exposed to various air pollutants both outdoors and indoors. Nowadays, people are spending relatively longer duration indoors. Hence, the supply of clean air inside homes, workplace, schools, day care facilities, healthcare facilities, and other private and public buildings is essential for the health and well being of the population. The hazardous pollutants could be emitted from buildings, construction materials and furniture/furnishings, or even from human activities such as combustion of coal for cooking/heating or influx/trapping of pollutants from outdoor environment. Good indoor air quality will impact directly on occupants’ health, comfort and work performance, and eliminate both short and long terms building-associated illnesses such as allergic responses, respiratory problems, eye irritation, bronchitis, pneumonia and so forth.

This study is designed to address the intimate interaction of environmental quality and human health and patient safety in a healthcare setting. The potential risk of the transmission and exposure to a particular disease from one patient to another will be high subsequent to direct or aerosol exposure in a crowded situation. Hence, appropriate interventions on identifying and regulating potential indoor air pollutants, and ensuring patient safety will be essential for all the healthcare facilities.

Methodology

  1. Indoor air quality assessment
  2. Air sampling
  3. Quantification of indoor air pollutants
  4. Aseptic culture technique
  5. Molecular techniques such as DNA extraction, PCR, DNA sequencing etc.
  6. Intervention study / guideline and policy development
  7. Statistical analysis